The application of Managed Pressure Drilling technology has been proved to be beneficial to the well construction in wells with narrow operating windows where it is necessary to work in different scenarios of fluid losses and influxes. Despite its major advantages, MPD still depends on high density muds to kill the well during tripping out; these operations are performed in a delicate balance that can be lost causing well control events while tripping. However, the combination of MPD with casing while drilling (CwD) techniques has raised as a new alternative to continue optimizing drilling projects. This integration has brought new challenges within MPD engineering and the need to adapt procedures to this new methodology to obtain excellent results. The objective of this article is to analyze changes in MPD, comparing cases of wells drilled with conventional BHA and wells drilled with casing. Software simulation analysis will be utilized to compare advantages and looking for opportunities in order to improve efficiency