000			01393nab a2200205 4500
005			20260520003105.0
008			260224s2013 xxu ing
041			_aInglés
245	0	0	_aDevelopment of Asymmetric Hydrogenation Catalysts via High Throughput Experimentation
260			_a _b _cene./feb. 2013
270			_a21/10/2013 ; 21/10/2013
300			_a9 p. ; 519-528
520			_aTranscripción del resumen del autor: The dynamics of drugs discovery imposes severe time constraints on the development chemist in charge of implementing the large scale production of a new Active Pharmaceutical Ingredient (API). This results in the use of well-established and robust transformations at the expense of the cost-efficiency and the sustainability of the process. In order to cope with the short development time and allow the implementation of new more efficient production technologies such as asymmetric hydrogenation, we have turned towards the use of high throughput experimentation for the discovery of new catalysts. The protocol for the preparation of a library of chiral ligands and its application to real-life pharmaceutical molecules is described in this article.
581			_a1
773	0		_tOil and Gas Science and Technology _g68
942			_cARTICULO
100	1		_aVries, J.G. de _953541
100	1		_aLefort, L. _953542
999			_c187936 _d187936